PI3K p85(alpha) Antibody 3 Publications

Mouse Monoclonal| Catalog number: 60225-1-Ig |CloneNo.: 4G3C11

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Freight/Packing

Con: 225 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, mouse, pig, rat

Positive WB detected in:
fetal human brain tissue, human brain tissue, mouse brain tissue, Neuro-2a cells, pig brain tissue, rat brain tissue

Positive IP detected in:
RAW 264.7 cells

Positive IHC detected in:
human prostate cancer tissue, human prostate cancer tissue, human skeletal muscle tissue, mouse brain tissue

Positive IF detected in:
HeLa cells, RAW 264.7 cells

Recommended dilution:
WB : 1:1000-1:8000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2a

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

Calculated molecular weight:
85 kDa

Observed molecular weight:
85 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PIK3R1

Synonyms
GRB1, p85, p85 ALPHA, PI 3 Kinase p85 alpha, PI 3-kinase p85α, PI3 kinase subunit p85 alpha, PI3K p85(alpha), PI3K regulatory subunit alpha, PIK3R1
Background

Phosphatidylinositol 3-kinase (PI3K) plays an important role in the metabolic actions of insulin and is required for adipogenesis. The PI3K pathway has also been identified as an important player in cancer development and progression. The Class IA PI3K heterodimer, which is composed of a P110 catalytic subunit and a P85 regulatory subunit, is activated upon association of the P85 subunit with upstream adaptor proteins or receptor tyrosine kinases. Mutations in PIK3R1 are implicated in cases of breast cancer and associated to SHORT syndrome.


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