uPAR Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 10286-1-AP

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Freight/Packing

Con: 20 μg/150 μl

Choose size:

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Species specificity:
human, mouse

Positive WB detected in:
RAW 264.7 cells, RAW264.7 cells

Positive IP detected in:
RAW 264.7 cells

Positive FC detected in:
U-937 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
plasminogen activator, urokinase receptor

Calculated molecular weight:
37 kDa

Observed molecular weight:
35-70 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PLAUR

Synonyms
CD87, MO3, PLAUR, U PAR, UPAR, URKR
Background

Urokinase plasminogen activator surface receptor (uPAR, also known as PLAUR or CD87) is a 45-65 kDa, highly glycosylated, GPI-anchored membrane protein. In addition to the membrane-anchored form, uPAR is released from the plasma membrane by cleavage of the GPI anchor and can be found as a soluble form (suPAR). uPAR contains three homologous domains (D1-D3) of which the N-terminal one (D1) represents the uPA-binding domain. After binding to uPAR, uPA cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodelling and in many human cancers, in which it frequently indicates poor prognosis. (PMID 20027185; 12461559)


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