PML Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 21041-1-AP

  • Print page
  • Download PDF

Be the first to review this product



Con: 42 μg/150 μl

Choose size:

Please visit your regions distributor:

Species specificity:

Positive WB detected in:
HEK-293 cells

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human liver tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:200-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:100-1:400
IF : 1:50-1:500

Product Information


Purification method:
Antigen affinity purification


PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Full name:
promyelocytic leukemia

Calculated molecular weight:
882aa,98 kDa

Observed molecular weight:
120 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol

MYL, PML, PP8675, promyelocytic leukemia, RING finger protein 71, RNF71, TRIM19

PML, also named as MYL, RNF71 and TRIM19, is a member of RBCC/TRIM family of proteins that possess a RING finger domain, B-box, and coiled-coil domain. It functions as tumor suppressor. PML is required for normal, caspase-dependent apoptosis in response to DNA damage, FAS, TNF, or interferons. It plays a role in transcription regulation, DNA damage response, DNA repair and chromatin organization. PML plays a role in processes regulated by retinoic acid, regulation of cell division, terminal differentiation of myeloid precursor cells and differentiation of neural progenitor cells. It regulates PTEN compartmentalization through the inhibition of USP7-mediated deubiquitinylation. A large number of alternative spliced transcripts are synthesized from the PML gene, resulting in a variety of PML proteins ranging in molecular weight from 48-97 kDa(PMID:11704850).

to top