OCT1 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 10387-1-AP

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Freight/Packing

Con: 35 μg/150 μl

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Species specificity:
human, pig, mouse

Positive WB detected in:
HeLa cells, HEK-293 cells, NCCIT cell

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human colon cancer tissue,human lymphoma tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:50-1:500
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
POU class 2 homeobox 1

Calculated molecular weight:
76 kDa

Observed molecular weight:
90 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
POU2F1

Synonyms
NF A1, Oct 1, OCT1, Octamer binding protein 1, OTF 1, OTF1, POU class 2 homeobox 1, POU2F1
Background

The POU class 2 homeobox 1 (POU2F1), also known as octamer-binding transcription factor-1 (OCT-1), is a ubiquitous nuclear protein that regulates the transcription of target genes by binding to a cis-acting octamer element(5’-ATTTGCAT-3’). It participated in the regulation of housekeeping genes, including histone H2B and snRNAs, for cell differentiation and proliferation [PMID:3462701]. In addition, it functions as a cellular stress sensor that modulates activities of tissue-specific target genes involved in immune and inflammatory responses [PMID:16322220]. It also acts as a repressor for the cytokine-inducible, NF-kB-dependent expression of E-selectin and the vascular cell adhesion molecule during vascular inflammation. Otherwise, it can interact with nuclear hormone receptors, such as the retinoid X receptor, the thyroid hormone receptor and the glucocorticoid receptor, and influence their transcription activity[PMID:17192276].


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