PRG2 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 10766-1-AP

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Freight/Packing

Con: 35 μg/150 μl

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Species specificity:
human

Positive WB detected in:
Transfected HEK-293 cells

Positive IHC detected in:
human breast cancer tissue

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)

Calculated molecular weight:
25 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PRG2

Synonyms
BMPG, Bone marrow proteoglycan, EMBP, MBP, MBP1, PRG2, Proteoglycan 2
Background

PRG2, also known as BMPG, has 222 amino acid residues with a 16 N-terminal signal sequence, so the mature form has 206 amino acid residues. High levels of PRG2 are present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein can be cleaved into eosinophil granule major basic protein (MBP), which is the major constituent of the crystalline core of the eosinophil granule. MBP is highly basic and toxic to both mammalian cells and parasites, and it functions in the defense against invading parasites (PMID: 21270431).


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