PSMD2 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 14748-1-AP

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Freight/Packing

Con: 32 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HL-60 cells, A431 cells, HeLa cells, human heart tissue, K-562 cells, mouse heart tissue, mouse skeletal muscle tissue, rat heart tissue

Positive IP detected in:
K-562 cells

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2

Calculated molecular weight:
100 kDa

Observed molecular weight:
97 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PSMD2

Synonyms
26S proteasome subunit p97, P97, Protein 55.11, PSMD2, Rpn1, S2, TRAP2
Background

Tumor necrosis factor type 1 receptor-associated protein 2 (TRAP2), encoded by PSMD2 gene, is a non-ATPase regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. TRAP2 may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor.


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