PTEN Antibody 16 Publications

Rabbit Polyclonal| Catalog number: 22034-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 46 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
DU 145 cells,mouse testis tissue, HeLa cells, MKN-45 cells, mouse thymus tissue

Positive IP detected in:
DU 145 cells

Positive IHC detected in:
human prostate cancer tissue, human breast cancer tissue, human colon cancer tissue, human prostate cancer tissue, human testis tissue, mouse brain tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
phosphatase and tensin homolog

Calculated molecular weight:
47 kDa

Observed molecular weight:
55 kDa, 68 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PTEN

Synonyms
10q23del, Bannayan Zonana syndrome, BC005821, BZS, ITGA 2, MGC11227, MHAM, MMAC1, Multiple hamartoma (Cowden syndrome), phosphatase and tensin homolog, PTEN, PTEN1, TEP1
Background

PTEN(Phosphatase and tensin homolog) is also named as MMAC1, TEP1 and it modulates cell cycle progression and cell survival (blockage) through down-regulating the positive cell cycle-regulator (cycle D1) by its phosphatase activity and up-regulating the negative cell cycle regulator p21 (by its lipid phosphatase activity). PTEN is an important tumor suppressor whose inactivation frequency in cancers is ranked second after p53 tumor suppressor inactivation. PTEN is a 403-residue protein structured in an amino (N)-terminal phosphatase domain and a carboxy (C)-terminal C2 domain that binds phospholipid membranes.(PMID:14749127). There are some report showing that SUMOylation appears to be a positive regulator in controlling PTEN membrane association, whereas phosphorylation is a negative regulator that may neutralize SUMOylation through intramolecular electrostatic interactions (PMID:22713753). This antibody can recognize two isoforms with MW of 55kDa and 68 kDa.


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