COX2 Antibody 37 Publications

Rabbit Polyclonal| Catalog number: 12375-1-AP

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Freight/Packing

Con: 39 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
LPS treated HEK-293 cells, HEK-293 cells, mouse embryo tissue, rat stomach tissue

Positive IHC detected in:
human lung cancer tissue, human colon cancer tissue, human kidney tissue, human lung tissue, human lung cancer tissue, human ovary tissue, human placenta tissue, human prostate hyperplasia tissue, human testis tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:100-1:400
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

Calculated molecular weight:
604aa,68 kDa

Observed molecular weight:
70-74 kDa, 64 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PTGS2

Synonyms
COX 2, COX2, Cyclooxygenase 2, GRIPGHS, hCox 2, PGG/HS, PGH synthase 2, PGHS 2, PHS 2, PHS II, Prostaglandin G/H synthase 2, Prostaglandin H2 synthase 2, PTGS2
Background

COX2 (Prostaglandin G/H synthase 2; PTGS2) mediates the formation of prostaglandins from arachidonate. Its subunit structure is homodimer. The fully N-glycosylated PTGS2 is 72–74 kDa and the aglycosylated is 66 kDa(PMID:19656660 ). It also expresses a band of 39 kDa after unspecific cleavage(PMID:17509125 ). The 50 kDa band of fragmented PTGS2 has also previously been detected in AD brains(PMID:14724276 ).


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