PYCR1 Antibody 11 Publications

Rabbit Polyclonal| Catalog number: 13108-1-AP

Featured Product KD/KO validated

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Con: 46 μg/150 μl

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Species specificity:
human, mouse, rat, zebrafish

Positive WB detected in:
HT-1080 cells, HeLa cells

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
human prostate cancer tissue

Positive IF detected in:
MCF-7 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:100-1:400
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
pyrroline-5-carboxylate reductase 1

Calculated molecular weight:
319aa,33.8 kDa

Observed molecular weight:
33 kDa, 35 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PYCR1

Synonyms
P5C, P5C reductase 1, P5CR, P5CR 1, PIG45, PP222, PYCR, PYCR1
Background

PYCR1,also named as P5CR1, belongs to the pyrroline-5-carboxylate reductase family. It is a housekeeping enzyme that catalyzes the last step in proline biosynthesis. PYCR1 can utilize both NAD and NADP, but has higher affinity for NAD. It is involved in the cellular response to oxidative stress. Mutation in PYCR1 will cause ARCL type II(ARCL2B ). Some mutation will cause DeBarsy syndrome (DBS) which is characterized by progeroid features, ophthalmological abnormalities, intrauterine growth retardation, and cutis laxa. The MW of PYCR1 is about 33-35 kDa. PYCR1 has 3 isoforms produced by alternative splicing.


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