QSOX1 Antibody 8 Publications

Rabbit Polyclonal| Catalog number: 12713-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 51 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
SW 1990 cells, HeLa cells, HT-1080 cells, human heart tissue, human placenta tissue, MCF-7 cells, mouse heart tissue, SW 1990 cells

Positive IP detected in:
SW 1990 cells

Positive IHC detected in:
human heart tissue

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
quiescin Q6 sulfhydryl oxidase 1

Calculated molecular weight:
747aa,83 kDa

Observed molecular weight:
65-94 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
QSOX1

Synonyms
FLJ34858, hQSOX, Q6, QSCN6, QSOX1, Quiescin Q6, Sulfhydryl oxidase 1
Background

QSOX1(Sulfhydryl oxidase 1) catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.It has two isoforms with the molecular weight of 67 kda and 83 kDa,respectively. It is detected a band of 95 Kda in HT1080 cell lines (PMID:17331072).Isoform 1 is expressed on golgi apparatus membrane and isoform 2 is secreted (PMID:10708601). The isoform1(QSOX1a) is the full length of QSOX1, approximately 78 kd; and the isoform2(QSOX1b) is the splicing form, approximately 62kd(PMID:14633699; 2496424). QSOX1 is highly expressed in tumor cell lines but is not expressed in adjacent normal cells (PMID:21989104).


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