RAB27A Antibody 12 Publications

Rabbit Polyclonal| Catalog number: 17817-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 50 μg/150 μl

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Species specificity:
human, Chicken, mouse, rat

Positive WB detected in:
HL-60 cells,Jurkat cells, L02 cells, human liver tissue, K562 , K-562 cells, Apoptosised HeLa cells, HeLa cells

Positive IP detected in:
K-562 cells

Positive IHC detected in:
human stomach tissue, human kidney tissue, human liver cancer tissue, human stomach tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:500
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
RAB27A, member RAS oncogene family

Calculated molecular weight:
221aa,25 kDa

Observed molecular weight:
25-27 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
RAB27A

Synonyms
GS2, GTP binding protein Ram, HsT18676, Rab 27, RAB27, RAB27A, RAM, Ras related protein Rab 27A
Background

Rab27a is a member of a large family of Ras-related small GTPases. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Recent studies suggest that Rab27a is associated with melanosomes in pigmented cells and regulates melanosome transport via its interaction with actin-based cellular motors such as myosin Va and myosin VIIa. RAB27A is also required for regulated secretion in cytotoxic T lymphocytes. Rab27a is implicated in several diseases, including Griscelli syndrome, choroideremia, and the Hermansky-Pudlak syndrome mouse model, gunmetal.


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