RARB Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 14013-1-AP

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Freight/Packing

Con: 23 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
Y79 cells

Positive IHC detected in:
human liver cancer tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
retinoic acid receptor, beta

Calculated molecular weight:
50 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
RARB

Synonyms
HAP, HBV activated protein, NR1B2, RAR beta, RAR epsilon, RARB, Retinoic acid receptor beta, retinoic acid receptor, beta, RRB2
Background

Retinoic acid receptors (RARs) are important mediators of retinoid signaling in morphogenesis, development, and cell differentiation. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes [PMID:12554770]. They can bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, they act mainly as activators of gene expression due to weak binding to corepressors. In concert with RARG, RARs are required for skeletal growth, matrix homeostasis and growth plate function. RARB is one isotypes of RARs [PMID:12834868]


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