p107 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 13354-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 55 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse testis tissue, COLO 320 cells

Positive IP detected in:
mouse testis tissue

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
retinoblastoma-like 1 (p107)

Calculated molecular weight:
1068aa,119 kDa

Observed molecular weight:
119 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
RBL1

Synonyms
CP107, p107, PRB1, RBL1, retinoblastoma like 1 (p107), Retinoblastoma like protein 1
Background

Retinoblastoma-like protein 1, also named RBL1, p107, is a member of E1A-binding proteins, which contains a A/B pocket, or pRb. Via this structure, RBL1 can bind to viral oncoproteins and other perteins containing LXCXE motif. It regulates cell proliferation via phosphorylation-sensitive interactions with E2F transcription factors and other proteins. Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression.(uniprot). It has been reported there are two transcirpts variants of RBL1, which encode a 119-kd protein and a 68-kd protein(PMID:7490090).


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