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p107 Antibody 5 Publications

Rabbit Polyclonal| Catalog number: 13354-1-AP

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Con: 55 μg/150 μl

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Tested Applications

Applications:
WB, IP, ELISA
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p107 Antibody WB mouse testis tissue 13354-1-AP

mouse testis tissue were subjected to SDS PAGE followed by western blot with 13354-1-AP(p107 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours

p107 Antibody IP mouse testis tissue 13354-1-AP

IP Result of anti-p107 (IP:13354-1-AP, 4ug; Detection:13354-1-AP 1:500) with mouse testis tissue lysate 4000ug.

Species specificity:
human, mouse, rat
Positive WB detected in:
mouse testis tissue, COLO 320 cells
Positive IP detected in:
mouse testis tissue
Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
Sample-dependent, check data in Validation tab

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
p107 fusion protein Ag4146
Full name:
retinoblastoma-like 1 (p107)
Calculated molecular weight:
1068aa,119 kDa
Observed molecular weight:
119 kDa
GenBank accession number:
BC032247
Gene ID (NCBI):
5933
Gene symbol
RBL1
Synonyms
CP107, p107, PRB1, RBL1, retinoblastoma like 1 (p107), Retinoblastoma like protein 1

Background

Retinoblastoma-like protein 1, also named RBL1, p107, is a member of E1A-binding proteins, which contains a A/B pocket, or pRb. Via this structure, RBL1 can bind to viral oncoproteins and other perteins containing LXCXE motif. It regulates cell proliferation via phosphorylation-sensitive interactions with E2F transcription factors and other proteins. Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression.(uniprot). It has been reported there are two transcirpts variants of RBL1, which encode a 119-kd protein and a 68-kd protein(PMID:7490090).


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