RSK2 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 23762-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 54 μg/150 μl

Choose size:

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Species specificity:
human, mouse

Positive WB detected in:
K-562 cells, HepG2 cells, MCF-7 cells, mouse heart tissue, NIH/3T3 cells

Positive IP detected in:
K-562 cells

Positive IHC detected in:
human kidney tissue

Positive IF detected in:
HepG2 cells, HUVEC cells, mouse brain tissue

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
ribosomal protein S6 kinase, 90kDa, polypeptide 3

Calculated molecular weight:
740aa,84 kDa

Observed molecular weight:
84 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
RPS6KA3

Synonyms
CLS, HU 3, ISPK 1, ISPK1, MAPKAP kinase 1b, MAPKAPK 1b, MAPKAPK1B, MRX19, p90 RSK 3, p90 RSK2, p90RSK3, pp90RSK2, Ribosomal S6 kinase 2, RPS6KA3, RSK, RSK 2, RSK2, S6K alpha 3, S6K alpha3
Background

RPS6KA3(Ribosomal protein S6 kinase alpha-3) is also named as ISPK1, MAPKAPK1B, RSK2 and belongs to the protein kinase superfamily. It localizes at the kinetochores under spindle checkpoint conditions, and during mitosis, associated with the centrosomes, the spindle and at the mid-body(PMID:20383198). It is required for epidermal growth factor activated phosphorylation of histone H3, which may cause chromatin remodeling and facilitate gene transcription and maybe playing an essential regulatory role in protein synthesis during cell proliferation.


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