Raptor Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 20984-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 119 μg/150 μl

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Species specificity:
human, rat, mouse, rice

Positive WB detected in:
HeLa cells,MCF-7 cells, HepG2 cells , HepG2 cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human kidney tissue, human kidney tissue, human skeletal muscle tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
raptor

Calculated molecular weight:
149 kDa

Observed molecular weight:
130-150 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
KIAA1303

Synonyms
KIAA1303, raptor, RPTOR
Background

RPTOR, also named as KIAA1303 and RAPTOR Belongs to the WD repeat RAPTOR family. It is involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino-acids. Amino-acid-signaling to mTORC1 is mediated by Rag GTPases, which cause amino-acid-induced relocalization of mTOR within the endomembrane system. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. The antibody is specific to RPTOR.


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