RRM1 Antibody 2 Publications

Mouse Monoclonal| Catalog number: 60073-1-Ig |CloneNo.: 4C12E10

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Freight/Packing

Con: 225 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
K-562 cells

Positive IP detected in:
K-562 cells

Positive IHC detected in:
human lung cancer tissue, human breast cancer tissue, human cervical cancer tissue, human lung cancer tissue, human ovary tumor tissue

Positive FC detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200

Product Information


Source:
Mouse

Purification method:
Caprylic acid/ammonium sulfate precipitation

Isotype:
IgG1

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
ribonucleotide reductase M1

Calculated molecular weight:
90 kDa

Observed molecular weight:
90 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
RRM1

Synonyms
R1, ribonucleotide reductase M1, RIR1, RR1, RRM1
Background

Ribonucleoside-diphosphate reductase functions as a heterodimer of a large and a small subunits in deoxyribonucleotide synthesis. RRM1 constitutes to the large subunit (R1) of ribonucleotide reductase, and it can either form heterodimer with small subunit RRM or RRM2B. RRM1 provides the precursors necessary for DNA synthesis. RRM1 can not be detected in quiescent cells, while its mRNA and protein are present throughout the cell cycle in cycling cells(PMID:8188248). Researches showed that RRM1 is involved in carcinogenesis, tumor progression, and the resistance of non-small-cell lung cancer (NSCLC) to treatment. Low level expression of RRM1 in NSCLC is associated with poor survival(PMID:17314339).


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