RSAD2 Polyclonal antibody
RSAD2 Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
mouse, human, rat
Applications
WB,ELISA
Conjugate
Unconjugated
Cat no : 11833-1-AP
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| Sample-dependent, check data in validation data gallery | |
Published Applications
| WB | See 6 publications below |
Product Information
11833-1-AP targets RSAD2 in WB,ELISA applications and shows reactivity with mouse, human, rat samples.
| Tested Reactivity | mouse, human, rat |
| Cited Reactivity | human, mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | RSAD2 fusion protein Ag2409 |
| Full Name | radical S-adenosyl methionine domain containing 2 |
| Calculated molecular weight | 361 aa, 42 kDa |
| GenBank accession number | BC017969 |
| Gene symbol | RSAD2 |
| Gene ID (NCBI) | 91543 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
RSAD2 (radical S-adenosyl methionine domain-containing protein 2), also known as CIG5 (cytomegalovirus-induced gene 5 protein), vig1, viperin or CIG33, displays antiviral effect against HIV-1 virus, hepatitis C virus, human cytomegalovirus, and aphaviruses. Expression of the protein can be induced by interferon. Western blot analysis of IFNG-treated cells revealed 43 kD/35kd bands.
Protocols
| Product Specific Protocols | |
|---|---|
| WB protocol for RSAD2 antibody 11833-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
| Species | Application | Title |
|---|---|---|
J Biol Chem Viperin interacts with the kinase IRAK1 and the E3 ubiquitin ligase TRAF6, coupling innate immune signaling to antiviral ribonucleotide synthesis. | ||
FEBS Lett Viperin, through its radical-SAM activity, depletes cellular nucleotide pools and interferes with mitochondrial metabolism to inhibit viral replication. | ||
J Biol Chem Targeting viperin to the mitochondrion inhibits the thiolase activity of the trifunctional enzyme complex. | ||
J Virol Identification of alpha interferon-induced genes associated with antiviral activity in Daudi cells and characterization of IFIT3 as a novel antiviral gene. | ||
J Neuroinflammation Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation. |