RSAD2 Polyclonal antibody

RSAD2 Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

mouse, human, rat

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 11833-1-AP

Synonyms

2510004L01Rik, cig33, cig5, RSAD2, vig1, Viperin



Tested Applications

Recommended dilution

ApplicationDilution
Sample-dependent, check data in validation data gallery

Published Applications

WBSee 5 publications below

Product Information

11833-1-AP targets RSAD2 in WB, ELISA applications and shows reactivity with mouse, human, rat samples.

Tested Reactivity mouse, human, rat
Cited Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen RSAD2 fusion protein Ag2409
Full Name radical S-adenosyl methionine domain containing 2
Calculated molecular weight 361 aa, 42 kDa
GenBank accession numberBC017969
Gene symbol RSAD2
Gene ID (NCBI) 91543
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

RSAD2 (radical S-adenosyl methionine domain-containing protein 2), also known as CIG5 (cytomegalovirus-induced gene 5 protein), vig1, viperin or CIG33, displays antiviral effect against HIV-1 virus, hepatitis C virus, human cytomegalovirus, and aphaviruses. Expression of the protein can be induced by interferon. Western blot analysis of IFNG-treated cells revealed 43 kD/35kd bands.

Protocols

Product Specific Protocols
WB protocol for RSAD2 antibody 11833-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
human

J Biol Chem

Viperin interacts with the kinase IRAK1 and the E3 ubiquitin ligase TRAF6,  coupling innate immune signaling to antiviral ribonucleotide synthesis.

Authors - Arti B Dumbrepatil

FEBS Lett

Viperin, through its radical-SAM activity, depletes cellular nucleotide pools and interferes with mitochondrial metabolism to inhibit viral replication.

Authors - Kourosh H Ebrahimi
humanWB

PLoS One

PMID: 25461762

Authors - Jing Ru
humanWB

J Virol

Identification of alpha interferon-induced genes associated with antiviral activity in Daudi cells and characterization of IFIT3 as a novel antiviral gene.

Authors - Schmeisser H H
human,mouseWB

J Neuroinflammation

Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation.

Authors - Sylvia Torres-Odio
humanWB

Eur Respir J

PMID: 20150207

Authors - Gielen V V