RSAD2 Polyclonal antibody
RSAD2 Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
mouse, human, rat
Applications
WB,ELISA
Conjugate
Unconjugated
Cat no : 11833-1-AP
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
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Sample-dependent, check data in validation data gallery |
Published Applications
WB | See 6 publications below |
Product Information
11833-1-AP targets RSAD2 in WB,ELISA applications and shows reactivity with mouse, human, rat samples.
Tested Reactivity | mouse, human, rat |
Cited Reactivity | human, mouse |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | RSAD2 fusion protein Ag2409 |
Full Name | radical S-adenosyl methionine domain containing 2 |
Calculated molecular weight | 361 aa, 42 kDa |
GenBank accession number | BC017969 |
Gene symbol | RSAD2 |
Gene ID (NCBI) | 91543 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
RSAD2 (radical S-adenosyl methionine domain-containing protein 2), also known as CIG5 (cytomegalovirus-induced gene 5 protein), vig1, viperin or CIG33, displays antiviral effect against HIV-1 virus, hepatitis C virus, human cytomegalovirus, and aphaviruses. Expression of the protein can be induced by interferon. Western blot analysis of IFNG-treated cells revealed 43 kD/35kd bands.
Protocols
Product Specific Protocols | |
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WB protocol for RSAD2 antibody 11833-1-AP | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |
Publications
Species | Application | Title |
---|---|---|
J Biol Chem Viperin interacts with the kinase IRAK1 and the E3 ubiquitin ligase TRAF6, coupling innate immune signaling to antiviral ribonucleotide synthesis. | ||
FEBS Lett Viperin, through its radical-SAM activity, depletes cellular nucleotide pools and interferes with mitochondrial metabolism to inhibit viral replication. | ||
J Biol Chem Targeting viperin to the mitochondrion inhibits the thiolase activity of the trifunctional enzyme complex. | ||
J Virol Identification of alpha interferon-induced genes associated with antiviral activity in Daudi cells and characterization of IFIT3 as a novel antiviral gene. | ||
J Neuroinflammation Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation. |