RUNX1 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 25315-1-AP

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Freight/Packing

Con: 56 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
mouse thymus tissue, Jurkat cells

Positive IP detected in:
Jurkat cells

Positive IHC detected in:
human prostate cancer tissue, human ovary tumor tissue, human prostate cancer tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:50-1:500
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
runt-related transcription factor 1

Calculated molecular weight:
480aa,52 kDa

Observed molecular weight:
49 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
RUNX1

Synonyms
AML1, AML1 EVI 1, AMLCR1, CBF alpha 2, CBFA2, EVI 1, Oncogene AML 1, PEA2 alpha B, PEBP2 alpha B, PEBP2aB, RUNX1
Background

Runt-related transcription factor 1 (RUNX1), also named as AML1 or CBF alpha 2, is 453 amino acid protein, which contains one Runt domain. RUNX1 localizes in the nucleus and is expressed in all tissues except brain and heart. RUNX1 is involved in hematopoiesis and is frequently targeted in human leukemia by chromosomal translocations that fuse the DNA-binding domain of RUNX1 to other transcription factors and corepressor molecules. In addition to its role in leukemogenesis, RUNX1 is also involved in sensory neuron diversification.


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