RXRB Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 14684-1-AP

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Freight/Packing

Con: 31 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
NIH/3T3 cells, MCF-7 cells

Positive IP detected in:
MCF-7 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
retinoid X receptor, beta

Calculated molecular weight:
57 kDa

Observed molecular weight:
57 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
RXRB

Synonyms
DAUDI6, H 2RIIBP, NR2B2, RCoR 1, Retinoid X receptor beta, retinoid X receptor, beta, RXRB
Background

Retinoid X receptor beta (RXRβ), like other members of the RXR subfamily, possesses a characteristic tripartite modular structure consisting of (a) a highly conserved central region containing the C4/C5 zinc-finger domain, which is responsible for DNA binding; (b) a relatively well-conserved C-terminal region, which contains the hormone binding and dimerization domains; and © a variable N-terminal domain, which has been implicated in either transactivation or repression of target genes. Variability within the N-terminal domain is thought to be the result of alternative splicing and/or differential promoter usage. The murine RXRβ was initially identified because of its ability to bind to the regulatory region II in the murine major histocompatability complex (MHC) class I promoter and is therefore also referred to as H-2RIIBP. Genetic ablation of murine Rxrb produced approximately 50% lethality in utero and males that survived had defects of spermatazoa, which resulted in sterility. Further studies revealed that expression of a Rxrb mutant with an impaired AF-2 core led to abnormal lipid metabolism in Sertoli cells, suggesting functional interactions between Rxrb and other nuclear receptors that control lipid metabolism. This antibody can recognize the RXRβprotein, and give a 58kd band.


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