S100 beta Antibody 5 Publications

Rabbit Polyclonal| Catalog number: 15146-1-AP

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Freight/Packing

Con: 58 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
A375 cells, human brain tissue, human testis tissue, mouse brain tissue

Positive IHC detected in:
human malignant melanoma tissue, human breast cancer tissue, human gliomas tissue, human malignant melanoma tissue, human skin cancer tissue

Positive IF detected in:
A375 cells

Recommended dilution:
WB : 1:200-1:1000
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
S100 calcium binding protein B

Calculated molecular weight:
11 kDa

Observed molecular weight:
11 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
S100B

Synonyms
NEF, Protein S100 B, S 100 protein beta chain, S 100 protein subunit beta, S100, S100 calcium binding protein B, S100B, S100beta
Background

S100B is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs and has been implicated in the regulation of cellular activities such as metabolism, motility and proliferation. In the nervous system, S100B is constitutively released by astrocytes into the extracellular space and at nanomolar concentrations, it can promote neurite outgrowth and protect neurons against oxidative stress. Within the central nervous system (CNS), S100B is thought to be a marker for astroglial activation, linking astrocyte dysfunction to schizophrenia. In addition to astrocytes, S100B is released from many cell types, such as, adipocytes, chondrocytes, cardiomyocytes and lymphocytes. Serum S100B represents a new bomarker for mood disorders.


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