SCAP Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 12266-1-AP

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Con: 20 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
HEK-293 cells, K-562 cells

Positive IHC detected in:
human lung cancer tissue, human kidney tissue

Positive IF detected in:
HEK-293 cells

Recommended dilution:
WB : 1:200-1:1000
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Purification method:
Antigen affinity purification


PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Full name:
SREBF chaperone

Calculated molecular weight:
1279aa,140 kDa

Observed molecular weight:
140 kDa,96 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol

KIAA0199, SCAP, SREBF chaperone, SREBP cleavage-activating protein, Sterol regulatory element-binding protein cleavage-activating protein

SCAP is a regulatory protein that is required for the proteolytic cleavage of the sterol regulatory element-binding protein (SREBP). SCAP is an integral membrane protein located in the endoplasmic reticulum (ER). One of the cytosolic regions of SCAP contains a hexapeptide amino acid sequence, MELADL, that functions to detect cellular cholesterol. When cholesterol is present, SCAP undergoes a conformational change that prevents it from activating SREBP and cholesterol synthesis does not occur. SCAP has 4 isoforms with MW 140, 98, 96 and 85 kDa (refer to UniProt).

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