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SCD Antibody 7 Publications

Rabbit Polyclonal| Catalog number: 23393-1-AP

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Tested Applications

Applications:
IHC, ELISA
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SCD Antibody IHC human liver tissue 23393-1-AP

Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 23393-1-AP( SCD Antibody) at dilution of 1:200 (under 40x lens).

Species specificity:
human, rat, mouse
Positive IHC detected in:
human liver tissue, human brain tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Recommended dilution:
IHC : 1:20-1:200
Sample-dependent, check data in Validation tab

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
SCD fusion protein Ag13456
Full name:
stearoyl-CoA desaturase (delta-9-desaturase)
Calculated molecular weight:
355aa,41 kDa
Observed molecular weight:
40 kDa
GenBank accession number:
BC005807
Gene ID (NCBI):
6319
Gene symbol
SCD
Synonyms
Acyl CoA desaturase, Delta(9) desaturase, FADS5, Fatty acid desaturase, MSTP008, SCD, SCD1, SCDOS, Stearoyl CoA desaturase

Background

SCD (stearoyl-CoA desaturase) is a 37-45 kDa (PMID:10946019) microsomal fatty acid monodesaturase, also commonly known as 9-desaturase, which catalyses the committed step in the biosynthesis of mono-unsaturated fatty acids from saturated fatty acids. Five SCD genes (SCD1, SCD2, SCD3,SCD4 and SCD5) have been identified and characterized in mice and SCD1 and SCD2 are the main isoforms expressed in mouse liver and brain respectively, SCD3 is expressed exclusively in skin, whereas SCD4 is expressed predominantly in the heart. SCD1and SCD5 has been the only human SCD gene identified and characterized todate(PMID:15907797 ). The formation of homodimers and oligomers is an intrinsic property of SCD proteins, which may play an important role in regulating the half-life of the SCDenzymes, thus representing a novel regulatory mechanism for SCD enzymes, in addition to the transcriptional and post-translational regulations. A 32-kDa SCD1 degradation product identified may be caused by a major cleavage site at the C-terminus, thus representing a novel degradation product(PMID:15610069).


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