SCNN1A Antibody 5 Publications

Rabbit Polyclonal| Catalog number: 10924-2-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 28 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
PC-13 cells, HEK-293

Positive IHC detected in:
human kidney tissue

Positive IF detected in:
A549 cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
sodium channel, nonvoltage-gated 1 alpha

Calculated molecular weight:
75.7 kDa

Observed molecular weight:
60-70 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SCNN1A

Synonyms
Alpha ENaC, Alpha NaCH, ENaCa, ENaCalpha, FLJ21883, SCNEA, SCNN1, SCNN1A
Background

SCNN1A (sodium channel, non-voltage-gated 1 alpha), also known as ENaCA (epithelial Na(+) channel subunit alpha) or amiloride-sensitive sodium channel subunit alpha, is the alpha subunit of the epithelial Na(+) channel (ENaC). ENaC is expressed in the apical membrane of salt-absorbing epithelia of kidney, distal colon, and lung. ENaC is a non-voltage gated, constitutively active channel highly selective for sodium. It has an essential role in salt and fluid homeostasis across epithelial tissues. ENaC consists of three different subunits: alpha, beta, gamma. Mutations in the gene of SCNN1A have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It has been reported that full-length SCNN1A protein can be cleaved into 65- and 30-kDa fragments (PMID: 16477034; 18701608).


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