SESN3 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 11431-2-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 35 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells, A431 cells, A549 cells, HEK-293 cells, HeLa cells, HepG2 cells, mouse liver tissue, mouse ovary tissue

Recommended dilution:
WB : 1:500-1:1000

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
sestrin 3

Calculated molecular weight:
492aa,57 kDa

Observed molecular weight:
51-59 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SESN3

Synonyms
SESN3, SEST3, sestrin 3
Background

Sestrins, including sestrin-1 (PA26), sestrin-2 (Hi95), and sestrin-3, are 48 to 65 kDa cystein sulfinyl reductases and they modulate peroxide signaling and antioxidant defense. These proteins selectively reduce or repair hyperoxidized forms of typical 2-Cys peroxiredoxins within eukaryotes. Expression of these proteins is regulated by p53, a tumor suppressor protein. Sestrin 3 was identified as a forkhead box O (FoxO) target gene with antioxidant activity. Recently it was reported that sestrin 3 may play an important role in AKT induced increase in ROS and it might be a promising target in selectively killing cancer cells containing high levels of AKT activity.


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