SH2B1 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 12226-1-AP

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Freight/Packing

Con: 43 μg/150 μl

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Species specificity:
human

Positive WB detected in:
Transfected HEK-293 cells, HEK-293 cells

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human ovary tissue, human ovary tissue, human skeletal muscle tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
SH2B adaptor protein 1

Calculated molecular weight:
426aa,45 kDa

Observed molecular weight:
80 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SH2B1

Synonyms
DKFZp547G1110, FLJ30542, KIAA1299, PSM, SH2B, SH2B adapter protein 1, SH2B adaptor protein 1, SH2B1
Background

SH2B1 is a member of the SH2-domain containing mediators family. SH2B1 has been shown to interact with insulin receptor, Grb2, TrkA and Janus kinase 2. Variations close to or in the SH2B1 gene have been found to associate with obesity in two large genome wide association studies of body mass index (PMID: 19079260). SH2B1deletions are associated with severe early-onset obesity (PMID: 19966786).


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