Background

GLUT3 (SLC2A3) belongs to the glucose transporter family (GLUTs) which mediates the transport of glucose across cellular membranes in mammalian cells. There are three subclasses within GLUTs: class I comprises the classical transporters GLUT1-4 and GLUT14; class II contains the "odd" isoforms GLUT5, 7, 9, and 11; the isoforms GLUT6, 8, 10, 12 and the proton driven myoinositol transporter HMIT (GLUT13) belong to class III. GLUT3 is considered as a neuron-specific glucose transporter because of its dominant expression in the brain in various species. However, besides the brain GLUT3 is also expressed in tissues with high demand for glucose such as sperm, preimplantation embryos, circulating white blood cells, and an array of carcinoma cell lines.Recently GLUT3 has been identified as a sensitive and specific marker for embyonal carcinomas and yolk tumors.The GLUT14 is believed to be the duplicate gene of GLUT3 given to the high identity in sequence between them. This antibody was generated against the internal region of human GLUT3 and may cross-react with GLUT14. (23343953)