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SNAI1 Antibody 44 Publications

Rabbit Polyclonal| Catalog number: 13099-1-AP

Featured Product KD/KO validated

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Con: 45 μg/150 μl

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Tested Applications

Applications:
WB, IP, IHC, IF, ChIP, ELISA
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Images See all

SNAI1 Antibody WB mouse heart tissue 13099-1-AP

mouse heart tissue were subjected to SDS PAGE followed by western blot with 13099-1-AP(SNAI1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours

SNAI1 Antibody IP MCF-7 cells 13099-1-AP

IP Result of anti-SNAI1 (IP:13099-1-AP, 4ug; Detection:13099-1-AP 1:600) with MCF-7 cells lysate 1040ug.

Species specificity:
human, mouse, rat
Positive WB detected in:
mouse heart tissue, human heart tissue, COLO 320 cells
Positive IP detected in:
MCF-7 cells
Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB

Protocols

Product-specific protocols

Standard Protocols

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
SNAI1 fusion protein Ag3723
Full name:
snail homolog 1 (Drosophila)
Calculated molecular weight:
264aa,29 kDa
Observed molecular weight:
29 kDa
GenBank accession number:
BC012910
Gene ID (NCBI):
6615
Gene symbol
SNAI1
Synonyms
Protein sna, Protein snail homolog 1, SLUGH2, SNA, SNAH, SNAI1, snail homolog 1 (Drosophila), SNAIL1, Zinc finger protein SNAI1

Background

SNAI1, a member of SNAI1 family of protein, participates in the epithelial to mesenchymal transition(EMT) and formation and maintenance of embryonic mesoderm. The snail family share a common structural, that a highly conserved C-terminal region containing a zinc finger transcription factor. SNAI1 interacts with other corepressor, such as Ajuba, PRMT5 and SIN3a or HDAC1 and 2, to repress the target gene. As the phosphorylation modification of SNAI1 protein, the range of molecular weight of SNAI1 is about 25-30 kDa (PMID: 22276203 ). Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs.


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