SOCS3 Antibody 11 Publications

Rabbit Polyclonal| Catalog number: 14025-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 34 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
K-562 cells, HeLa cells, HepG2 cells

Positive IP detected in:
K-562 cells

Positive IHC detected in:
human heart tissue, human placenta tissue

Positive IF detected in:
Hela cells, HepG2 cells

Recommended dilution:
WB : 1:300-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:500
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
suppressor of cytokine signaling 3

Calculated molecular weight:
25 kDa

Observed molecular weight:
22-30 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SOCS3

Synonyms
ATOD4, CIS 3, CIS3, Cish3, SOCS 3, SOCS3, SSI 3, SSI3, STAT induced STAT inhibitor 3
Background

The suppressor of cytokine signaling (SOCS) family proteins are negative feedback system that inhibits cytokine signal transduction. One of the SOCS family, SOCS3, also named CIS3 and SSI3, is involved in inhibition of JAK/STAT pathway which regulates IL-6 signaling in vivo. SOCS3 can be rapidly trigger by a number of factors including interleukins, IFN-gamma and TNF-alpha. Pathology such as inflammatory response, wound repair and obesity and so on have been linked to SOCS3. Observed MW of SOCS3 is from 22-30 kDa(PMID: 24827536,PMID: 26260587, PMID: 26797799), consistent with the result of Catalog#14025-1-AP.


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