SP3 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 26584-1-AP

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Freight/Packing

Con: 58 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
PC-3 cells, C2C12 cell, COLO 320 cells

Recommended dilution:
WB : 1:500-1:1000

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
Sp3 transcription factor

Calculated molecular weight:
781aa,82 kDa

Observed molecular weight:
70, 115 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SP3

Synonyms
DKFZp686O1631, SP3, Sp3 transcription factor, SPR 2, Transcription factor Sp3
Background

SP3, also named as transcription factor Sp3, is a 781 amino acid protein, which contains 3 C2H2-type zinc fingers and belongs to the Sp1 C2H2-type zinc-finger protein family. SP3 localizes to the nuclear periphery and in nuclear dots when sumoylated. Some localization in PML nuclear bodies. SP3 is acetylated by histone acetyltransferase p300, deacetylated by HDACs and sumoylated on all isoforms. Sumoylated on 2 sites in longer isoforms with Lys-551 being the major site. Sumoylation at this site promotes nuclear localization to the nuclear periphery, nuclear dots and PML nuclear bodies. Sumoylation on Lys-551 represses the transactivation activity, except for the largest isoform, L-Sp3, which has little effect on transactivation. Alternate sumoylation and acetylation at Lys-551 also control transcriptional activity. There exits tow modified isoform and molecular weight of those are 70 kda and 115 kda.


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