STAM Antibody 7 Publications

Rabbit Polyclonal| Catalog number: 12434-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 60 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
Jurkat cells,Multi-cells , Y79 cells, mouse brain tissue

Positive IP detected in:
PC-3 cells

Positive IHC detected in:
human testis tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
signal transducing adaptor molecule (SH3 domain and ITAM motif) 1

Calculated molecular weight:
59 kDa

Observed molecular weight:
70 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
STAM

Synonyms
DKFZp686J2352, STAM, STAM 1, STAM1
Background

STAM, also named as STAM1, belongs to the STAM family. It is involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. STAM may also play a role in T-cell development. It is involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs). Together with HRS, STAM forms ESCRT-0. STAM was originally identified as an adaptor protein involved in cytokine signaling.(PMID:20505072)


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