Synaptotagmin-1 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 14511-1-AP

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Freight/Packing

Con: 30 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
human liver tissue, mouse testis tissue, Y79 cells

Positive IP detected in:
mouse testis tissue

Positive IHC detected in:
human liver cancer tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
synaptotagmin I

Calculated molecular weight:
48 kDa

Observed molecular weight:
65 kDa ,47 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SYT1

Synonyms
DKFZp781D2042, P65, SVP65, Synaptotagmin 1, synaptotagmin I, SYT, SYT1, SytI
Background

The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (PMID: 8058779). SYT1 (synaptotagmin I) was firstly identified as a 65-kDa protein with a wide distribution in neuronal and neurosecretory tissue (PMID: 7298720). Calcium binding to SYT1 participates in triggering neurotransmitter release at the synapse (PMID: 11242035). In addition to regulating exocytosis, SYT1 has also been implicated in endocytosis and neurite outgrowth (PMID: 15492212; 11078930; 10336114). This antibody recognizes endogenous SYT1, which has an experimentally determined molecular mass of 65-68 kDa. An additional band of 47 kDa could also be detected, which is corresponding to the calculated molecular weight of SYT1.


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