TAF15 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 24235-1-AP

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Freight/Packing

Con: 64 μg/150 μl

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Species specificity:
human

Positive WB detected in:
HEK-293 cells

Positive IHC detected in:
human testis tissue, human kidney tissue

Positive IF detected in:
HEK-293 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen Affinity purified

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa

Calculated molecular weight:
592aa,62 kDa

Observed molecular weight:
68 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TAF15

Synonyms
hTAFII68, RBP56, RNA binding protein 56, TAF(II)68, TAF15, TAF2N, TAFII68
Background

TAF15 (TAF2N or TAFII68) is a nuclear protein known to associate with a distinct subpopulation of transcription factor IID (TFIID), a multi-subunit complex that nucleates the pre-initiation complex on promoters of on protein-coding genes. TAF15 harbors a transcriptional activation domain, a RNA recognition motif and many Arg-Gly-Gly repeats that participate in RNA binding. TAF15 along with FUS and EWS constitutes the FET (FUS/EWS/TAF15) protein family of heterogeneous nuclear ribonucleoproteins (hnRNPs) class of RNA binding proteins that are multifunctional proteins implicated in numerous aspects of RNA processing/functions. TAF15 is a nuclear protein that shuttle between cytoplasm-nucleus and as RNA/ssDNA-binding protein, it play specific roles during transcription initiation at distinct promoters and enter the preinitiation complex together with the RNA polymerase II. TAF15 as well as other FET member genes are frequently translocated in sarcomas and rare hematopoietic as well as epithelial cancers. Moreover, dominant mutations in genes coding for four hnRNPs (TDP-43, FUS/TLS, TAF15, and EWS) are found in familial and sporadic cases of ALS and a chromosomal aberration involving TAF15/TAF2N is found in a form of extraskeletal myxoid chondrosarcomas (EMC).


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