• Featured Product
  • KD/KO Validated

TDO2 Polyclonal antibody

TDO2 Polyclonal Antibody for IHC, WB,ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat





Cat no : 15880-1-AP


TDO, TDO2, TO, TPH2, TRPO, Tryptamin 2,3 dioxygenase, tryptophan 2,3 dioxygenase, Tryptophan oxygenase, Tryptophan pyrrolase, Tryptophanase

Tested Applications

Positive WB detected inrat liver tissue, mouse liver tissue
Positive IHC detected inhuman liver cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

Western Blot (WB)WB : 1:200-1:1000
Immunohistochemistry (IHC)IHC : 1:100-1:400
Sample-dependent, check data in validation data gallery

Product Information

15880-1-AP targets TDO2 in WB, IHC,ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen TDO2 fusion protein Ag8642
Full Name tryptophan 2,3-dioxygenase
Calculated molecular weight 406 aa, 48 kDa
Observed molecular weight 48 kDa
GenBank accession numberBC005355
Gene symbol TDO2
Gene ID (NCBI) 6999
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

TDO2 (tryptophan 2,3-dioxygenase), IDO1 (indoleamine 2,3-dioxygenase 1) and IDO2 are three enzymes that catalyze the amino acid tryptophan into kynurenine in the kynurenine pathway (PMID: 23090118, 28469468). TDO2 plays an important role in neurological diseases such as Alzheimer's disease, Parkinson's disease and autism. Overexpression of TDO2 promoted tumor cell survival and was correlated with tumor grade and poor prognosis in triple negative breast cancer, brain tumors and esophageal squamous cell carcinoma. TDO2 may be a potential therapeutic target in some cancers. (PMID: 21976023, 30134247)


Product Specific Protocols
WB protocol for TDO2 antibody 15880-1-APDownload protocol
IHC protocol for TDO2 antibody 15880-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Mol Metab

Dysregulated transmethylation leading to hepatocellular carcinoma compromises redox homeostasis and glucose formation.

Authors - Curtis C Hughey

Signal Transduct Target Ther

The proatherosclerotic function of indoleamine 2, 3-dioxygenase 1 in the developmental stage of atherosclerosis.

Authors - Heng Liang

Toxicol Appl Pharmacol

Salinomycin promotes T-cell proliferation by inhibiting the expression and enzymatic activity of immunosuppressive indoleamine-2,3-dioxygenase in human breast cancer cells.

Authors - Azubuike Peter Ebokaiwe

Eur J Med Chem

Tryptophan 2,3-dioxygenase inhibitory activities of tryptanthrin derivatives.

Authors - Shengnan Zhang

Bioorg Chem

Evaluation and comparison of the commonly used bioassays of human indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO).

Authors - Shengnan Zhang

Eur J Med Chem

Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO).

Authors - Shulei Pan


The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.


Hala (Verified Customer) (03-10-2021)

works veryyy gooddd

  • Applications: Western Blot
  • Primary Antibody Dilution: 1/1000 - 1/2000
  • Cell Tissue Type: hepatoblastoma cells transduced with lentivirus expressing TDO2

Hala (Verified Customer) (12-15-2020)

so efficient

  • Applications: Western Blot
  • Primary Antibody Dilution: 1/750 - 1/1000
  • Cell Tissue Type: liver cells transduced with lentivirus expressing TDO2
TDO2 Antibody Western Blot validation (1/750 - 1/1000 dilution) in liver cells transduced with lentivirus expressing TDO2 (Cat no:15880-1-AP)