THOC7 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 17881-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 22 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse testis tissue, HEK-293 cells, HeLa cells, human liver tissue

Positive IHC detected in:
human kidney tissue, human brain tissue, human kidney tissue, human lung tissue, human spleen tissue, human testis tissue

Recommended dilution:
WB : 1:1000-1:4000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
THO complex 7 homolog (Drosophila)

Calculated molecular weight:
204aa,24 kDa

Observed molecular weight:
24 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
THOC7

Synonyms
FLJ23445, fSAP24, hTREX30, NIF3L1 binding protein 1, NIF3L1BP1, THO complex subunit 7 homolog, THOC7
Background

THOC7 is a member of the THO complex that associate with the mRNA export apparatus. It is required for efficient export of polyadenylated RNA. It acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.


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