TIMP1 Antibody 23 Publications

Rabbit Polyclonal| Catalog number: 10753-1-AP

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Freight/Packing

Con: 62 μg/150 μl

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Species specificity:
human, mouse, rat

Positive IHC detected in:
human breast cancer tissue, human breast cancer tissue, human pancreas tissue, human stomach cancer tissue, human thyroid cancer tissue

Positive IF detected in:
HepG2 cells, BxPC-3 cells

Recommended dilution:
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
TIMP metallopeptidase inhibitor 1

Calculated molecular weight:
23 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TIMP1

Synonyms
CLGI, Collagenase inhibitor, EPA, EPO, FLJ90373, HCI, Metalloproteinase inhibitor 1, TIMP, TIMP 1, TIMP1, TIMP-1
Background

Tissue Inhibitor of Metalloproteinases-1 (TIMP1) is a naturally occurring protein in the human organism regulating the activity of matrix metalloproteinases (MMPs). TIMP1 encodes a 931 base-pair mRNA and a 207 amino acid protein. Overexpression of TIMP1 can lead to a substantially increase of genes involved in proliferation, apoptosis and signal transduction. In addition, TIMP1 was found to decrease tumor cell sensitivity to multiple anticancer drugs by activation of downstream pathways and exhibited anti-apoptotic activity. Specifically, the TIMP1 could degrade cyclinB1 and activate the NF-kβ signaling pathway to protect breast cancer cells against chemotherapy-induced cell death.


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