TLR4 Antibody 22 Publications

Rabbit Polyclonal| Catalog number: 19811-1-AP

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Freight/Packing

Con: 35 μg/150 μl

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Species specificity:
human, mouse, rat, bovine

Positive WB detected in:
mouse liver tissue, rat liver tissue

Positive IHC detected in:
human placenta tissue, human liver cancer tissue, mouse brain tissue

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:100-1:400

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
toll-like receptor 4

Calculated molecular weight:
839aa,96 kDa

Observed molecular weight:
90-100 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TLR4

Synonyms
ARMD10, CD284, hToll, TLR4, TOLL, toll like receptor 4
Background

TLR4, also named as CD284, belongs to the Toll-like receptor family. TLR4 cooperates with LY96 and CD14 to mediates the innate immune response to bacterial lipopolysaccharide (LPS). TLR4 acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Three alternatively spliced transcript variants that encode different protein isoforms have been described. The calculated molecular weightsf three TLR4 isoforms are 96, 91, and 73 kDa.


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