TLR5 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 19810-1-AP

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Freight/Packing

Con: 24 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
A549 cells, HeLa cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human tonsillitis tissue, human ovary tissue

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
toll-like receptor 5

Calculated molecular weight:
858aa,98 kDa

Observed molecular weight:
90-98 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TLR5

Synonyms
FLJ10052, SLEB1, TIL3, TLR5, toll like receptor 5
Background

TLR5 belongs to the Toll-like receptor family which are important in the innate immune response to pathogens. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. TLR5 is known to recognize bacterial flagellin from invading mobile bacteria. TLR5 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Mutations in TLR5 gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.


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