TMPRSS2 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 14437-1-AP

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Freight/Packing

Con: 47 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
COLO 320 cells

Positive IHC detected in:
human colon cancer tissue, human colon cancer tissue, human prostate cancer tissue

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:100-1:400

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
transmembrane protease, serine 2

Calculated molecular weight:
54 kDa

Observed molecular weight:
54 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TMPRSS2

Synonyms
FLJ41954, PP9284, PRSS10, Serine protease 10, TMPRSS2
Background

TMPRSS2, also named as PRSS10, is a type II transmembrane serine protease which is highly expressed by the epithelium of the human prostate gland. TMPRSS2 may contribute to prostate tumour metastasis via the activation of PAR-2. TMPRSS2 is a Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions. TMPRSS2 is essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity. The MW od TMPRSS2 is about 65-70 kDa. And it can be cleaved in to some chains with MW 54 kDa, 31 kDa and 26 kDa.


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