p63 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 12143-1-AP

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Freight/Packing

Con: 36 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
A431 cells, A431 cells, Apoptosised HeLa cells, human heart tissue, mouse heart tissue, U-937 cells

Positive IP detected in:
A431 cells

Positive IHC detected in:
human tonsillitis tissue, human breast hyperplasia tissue

Positive IF detected in:
A431 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
tumor protein p63

Calculated molecular weight:
680aa,77 kDa

Observed molecular weight:
63-68 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TP63

Synonyms
AIS, B(p51A), B(p51B), CUSP, EEC3, KET, LMS, NBP, OFC8, p40, p51, p53CP, p63, p73H, p73L, RHS, SHFM4, TP53CP, TP53L, TP63, TP73L, Tumor protein 63, tumor protein p63, Tumor protein p73 like
Background

TP63, also named KET, P63, P73H, P73L and TP73L, belongs to the p53 family. It is a homologue of the tumor suppressor p53 and p73 genes. It is involved in malignancy acquisition and maintenance of cells. Unlike p53, the p63 gene encodes multiple isotypes with remarkably divergent abilities to transactivate p53 reporter genes and induce apoptosis. TP63 acts as a sequence specific DNA binding transcriptional activator or repressor. TP63 has 12 isoforms with MW 40kd(P40), 50kd(P60),63kd(P63) and 73kd(P73L). It is Nuclear stain.


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