TRAF6 Antibody 2 Publications

Mouse Monoclonal| Catalog number: 66498-1-Ig |CloneNo.: 1D1E1

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Freight/Packing

Con: 105 μg/150 μl

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Species specificity:
Human

Positive WB detected in:
HeLa cells

Positive IHC detected in:
mouse brain tissue, human heart tissue, human liver tissue

Recommended dilution:
WB : 1:2000-1:12000
IHC : 1:300-1:1200

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
TNF receptor-associated factor 6

Calculated molecular weight:
522aa,60 kDa

Observed molecular weight:
60 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TRAF6

Synonyms
RING finger protein 85, RNF85, TRAF6
Background

TRAF6 is a member of the TNF receptor associated factor (TRAF) protein family. TRAF6 is recognized as a signal transducer, which activates the NF-κB pathway in response to pro-inflammatory cytokines. TRAF6 has E3 ligase activity and is responsible for inducing Lys-63 (K63)-linked poly-ubiquitination chains, functioning together with E2 Ubc13/Uev1A complex to mediate IKK activation TRAF6 plays a crucial role in the regulation of the innate and adaptive immune responses.


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