TTF2 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 13722-1-AP

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Freight/Packing

Con: 78 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
A2780 cells

Positive IP detected in:
A2780 cells

Positive IHC detected in:
human ovary tumor tissue

Positive IF detected in:
Hela cells

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
transcription termination factor, RNA polymerase II

Calculated molecular weight:
1162aa,129 kDa

Observed molecular weight:
130 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TTF2

Synonyms
F2, HuF2, Lodestar homolog, Transcription release factor 2, TTF2
Background

Transcription elongation is an key target for control of eukaryotic gene expression. After initiating from a promoter, the RNA polymerase II elongation complex is subjected to a block to elongation by the action of components of N-TEF (negative transcription elongation factor) [PMID: 9748214]. Transcription termination factor 2 (TTF2) is a DsDNA-dependent ATPase that acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. It also contribute to mitotic transcription repression, and involved in pre-mRNA splicing[PMID:15125840, 12927788].


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