UHRF1 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 21402-1-AP

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Freight/Packing

Con: 36 μg/150 μl

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Species specificity:
human

Positive WB detected in:
HeLa cells, HeLa cells, MCF-7 cells

Positive IP detected in:
HeLa cells

Positive IF detected in:
HepG2 cells, Hela cells, HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
ubiquitin-like with PHD and ring finger domains 1

Calculated molecular weight:
806aa,91 kDa

Observed molecular weight:
91 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
UHRF1

Synonyms
FLJ21925, hNP95, HuNp95, ICBP90, Nuclear protein 95, RING finger protein 106, RNF106, Transcription factor ICBP90, UHRF1
Background

UHRF1, also named as ICBP90, NP95 and RNF106, is a putative E3 ubiquitin-protein ligase. It may participate in methylation-dependent transcriptional regulation. UHRF1 binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, and activates TOP2A expression. It is important for G1/S transition and may be involved in DNA repair and chromosomal stability. UHRF1's ability to repress its direct target gene expression is dependent on PHD(UHRF1) binding to unmodified H3R2.


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