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  • Featured Product
  • KD/KO Validated

USP38 Polyclonal antibody

USP38 Polyclonal Antibody for WB, IP, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IP, IHC, CoIP, ELISA

Conjugate

Unconjugated

Cat no : 17767-1-AP

Synonyms

Deubiquitinating enzyme 38, HP43.8KD, KIAA1891, Ubiquitin thiolesterase 38, USP38

Validation Data Gallery

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  • Western Blot (WB) analysis of HEK-293T cells using USP38 Polyclonal antibody (17767-1-AP)

    WB analysis of HEK-293T using 17767-1-AP

    HEK-293T cells were subjected to SDS PAGE followed by western blot with 17767-1-AP (USP38 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

  • Immunoprecipitation (IP) experiment of K-562 cells using USP38 Polyclonal antibody (17767-1-AP)

    IP experiment of K-562 using 17767-1-AP

    IP result of anti-USP38 (IP:17767-1-AP, 4ug; Detection:17767-1-AP 1:500) with K-562 cells lysate 3200ug.

Tested Applications

Positive WB detected inHEK-293T cells
Positive IP detected inK-562 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:200-1:1000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

17767-1-AP targets USP38 in WB, IP, IHC, CoIP, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen USP38 fusion protein Ag12172
Full Name ubiquitin specific peptidase 38
Calculated Molecular Weight 1042 aa, 117 kDa
Observed Molecular Weight 117 kDa
GenBank Accession NumberBC068975
Gene Symbol USP38
Gene ID (NCBI) 84640
RRIDAB_2213383
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Ubiquitin specific peptidase 38 (USP38) is a negative regulator of type I IFN signaling. USP38 can strongly induced the degradation of the active form of TBK1 after viral infection. USP38 may play a critical role in the maintenance of the balance between innate immune responses and tolerance through dynamic ubiquitin editing of TBK1 in response to viral infection and perhaps other infectious diseases or cancer. (PMID:27692986)

Protocols

Product Specific Protocols
WB protocol for USP38 antibody 17767-1-APDownload protocol
IP protocol for USP38 antibody 17767-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
mouseWB

J Exp Med

USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein.

Authors - Siyuan Chen
  • KO Validated
View Article
humanIHC,WB,CoIP

Oncogenesis

USP38 regulates the stemness and chemoresistance of human colorectal cancer via regulation of HDAC3.

Authors - Wei Zhan
  • KD Validated
View Article
humanWB,IHC,IP

Am J Cancer Res

Ubiquitin specific peptidase 38 promotes the progression of gastric cancer through upregulation of fatty acid synthase.

Authors - Zhi Zheng
  • KD Validated
View Article
humanWB

Int J Biochem Cell Biol

The deubiquitinase USP38 promotes cell proliferation through stabilizing c-Myc.

Authors - Zhijun Xu
View Article