VAMP8 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 15546-1-AP

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Freight/Packing

Con: 58 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HL-60 cells

Recommended dilution:
WB : 1:200-1:1000

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
vesicle-associated membrane protein 8 (endobrevin)

Calculated molecular weight:
11 kDa

Observed molecular weight:
15 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
VAMP8

Synonyms
EDB, Endobrevin, VAMP 8, VAMP8
Background

VAMP8, also named as endobrevin, is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family and the SNARE (soluble NSF-attachment protein receptor) superfamily. Characterized by a common sequence called the SNARE motif, SNARE proteins are involved in membrane fusion and vesicular transport (PMID: 11252968). VAMP8 is involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. It is required for dense-granule secretion in platelets and plays a role in regulated enzyme secretion in pancreatic acinar cells. VAMP8 is also involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells.


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