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VDR Antibody 5 Publications

Rabbit Polyclonal| Catalog number: 14526-1-AP

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Con: 73 μg/150 μl

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Tested Applications

Applications:
WB, IHC, ELISA
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VDR Antibody WB PC-3 cells 14526-1-AP

PC-3 cells were subjected to SDS PAGE followed by western blot with 14526-1-AP( VDR Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours

Species specificity:
human, mouse, rat, mature ewes
Positive WB detected in:
PC-3 cells
Recommended dilution:
WB : 1:500-1:2000
Sample-dependent, check data in Validation tab

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
VDR fusion protein Ag6012
Full name:
vitamin D (1,25- dihydroxyvitamin D3) receptor
Calculated molecular weight:
48 kDa
Observed molecular weight:
55 kDa
GenBank accession number:
BC060832
Gene ID (NCBI):
7421
Gene symbol
VDR
Synonyms
NR1I1, VDR, Vitamin D3 receptor

Background

The vitamin D receptor (VDR), also known as the calcitriol receptor, and also known as NR1I1 (nuclear receptor subfamily 1, group I, member 1), is a member of the nuclear receptor family of transcription factors. Upon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or trans-repression of specific gene products.It is an intracellular hormone receptor that specifically binds 1,25(OH)2D3 and mediates its effects. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A). A disorder of vitamin D metabolism results in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets. This antibody is a rabbit polyclonal antibody to human VDR.


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