VPS33B Antibody 6 Publications

Rabbit Polyclonal| Catalog number: 12195-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 37 μg/150 μl

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Species specificity:
human, mouse, rat, zebrafish

Positive WB detected in:
mouse testis tissue, HeLa cells, mouse skeletal muscle tissue

Positive IHC detected in:
human kidney tissue, human spleen tissue, human brain tissue, human testis tissue, human placenta tissue, human lung tissue, human medulloblastoma tissue, human ovary tissue, human colon cancer tissue

Positive IF detected in:
MCF-7 cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
vacuolar protein sorting 33 homolog B (yeast)

Calculated molecular weight:
617aa,71 kDa

Observed molecular weight:
71 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
VPS33B

Synonyms
FLJ14848, hVPS33B, VPS33B
Background

VPS33B, a homolog of yeast class C vacuolar protein sorting (vps) protein Vps33p, belongs to the STXBP/unc-18/SEC1 family. It may play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. VPS33B mediates phagolysosomal fusion in macrophages (PMID: 18474358). Defects in VPS33B account for most cases of arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome, which is a multisystem disorder associated with abnormalities in polarized liver and kidney cells (PMID: 20190753).


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