VPS41 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 13869-1-AP

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Con: 47 μg/150 μl

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Species specificity:
human

Positive WB detected in:
HepG2 cells, human brain tissue

Positive IHC detected in:
human liver tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:200-1:1000
IHC : 1:50-1:500
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
vacuolar protein sorting 41 homolog (S. cerevisiae)

Calculated molecular weight:
854aa,98 kDa

Observed molecular weight:
94 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
VPS41

Synonyms
HVPS41, hVps41p, HVSP41, S53, VPS41
Background

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. VPS41 (vacuolar protein sorting 41) is the human ortholog of yeast Vps41 protein. Yeast Vps41 is a subunit of AP3 (heterotetrameric adaptor protein complex 3) and HOPS (homotypic fusion and protein transport) complexes and is involved in trafficking of proteins from the late Golgi to the vacuole. In mammalian cells, Vps41 was found to be a member of HOPS complex, mediating the trafficking of proteins to lysosomes (PMID: 23173123). It has been reported that human VPS41 has a HOPS-independent function in the LAMP carrier pathway and also participates in lysosomal maturation, probably as part of the HOPS complex (PMID: 23322049).


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