VTI1A Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 12354-1-AP

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Freight/Packing

Con: 42 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
human brain tissue, human heart tissue, human kidney tissue, human lung tissue, MCF-7 cells, mouse brain tissue

Positive IP detected in:
MCF-7 cells

Positive IF detected in:
NIH/3T3 cells

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
vesicle transport through interaction with t-SNAREs homolog 1A (yeast)

Calculated molecular weight:
217aa,25 kDa

Observed molecular weight:
25-29 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
VTI1A

Synonyms
MVti1, Vti1 rp2, VTI1A
Background

Fusion between membranes is mediated by specific SNARE (soluble N-ethylmeleimide-sensitive factor attachment protein receptor) complexes. Two human SNARE proteins, VTI1A and VTI1B, are homologous to the yeast Q-SNARE Vtilp which is part of several SNARE complexes in different transport steps (PMID: 12067063). VTI1A is involved in transport between the endosome and the trans-Golgi network. The SNARE complex of STX10, STX16, VTI1A, and VAMP3 is required for MPR (mannose 6-phosphate receptors) transport from endosomes to the Golgi after delivering lysosomal enzymes to the endocytic pathway (PMID: 18195106). Transport from early/recycling endosomes to the TGN is mediated by the SNARE complex of STX6, STX16, VTI1A and VAMP4 (PMID: 11839770; 21807881).


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