VWF, VWFpp Antibody 11 Publications

Rabbit Polyclonal| Catalog number: 11778-1-AP

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Con: 40 μg/150 μl

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Species specificity:
human, mouse, rat, pig

Positive WB detected in:
Jurkat cells, Jurkat cells, mouse spleen tissue

Positive IP detected in:
mouse spleen tissue

Positive IHC detected in:
human tonsillitis tissue, human lung tissue, human spleen tissue

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:100-1:400

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
von Willebrand factor

Calculated molecular weight:
309 kDa

Observed molecular weight:
309-320 kDa,75-100 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
VWF

Synonyms
F8VWF, von Willebrand antigen II, von Willebrand factor, VWD, VWF
Background

Von Willebrand factor (vWF) is a large multimeric glycoprotein that is crucial to the hemostasis process. It supports platelet adhesion and carries factor VIII (FVIII). Deficiency of vWF results in von Willebrand disease (vWD), a common inherited bleeding disorder. The pre-pro-vWF is comprised of 2,813 amino acids (aa) which encompass a 22-aa signal peptide, a 741-aa large propeptide (vWF propeptide, vWFpp, also called von Willebrand antigen 2) and 2,050 aa making up the mature vWF. The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules. This antibody raised against the N-terminal region (residues 56-256 aa) of pre-pro-vWF recognizes von Willebrand antigen 2 (75-100 kDa) and pro-vWF (309-320 kDa). (PMID: 9759493; 12067899; 22452980; 8874191)


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