CRM1 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 12915-1-AP

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Freight/Packing

Con: 28 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells, HT-1080 cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human heart tissue, human heart tissue, human kidney tissue

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
exportin 1 (CRM1 homolog, yeast)

Calculated molecular weight:
1071aa,123 kDa

Observed molecular weight:
100-110 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
XPO1

Synonyms
CRM1, DKFZp686B1823, Exp1, Exportin 1, XPO1
Background

CRM1 (chromosome region maintenance 1, also known as exportin-1 or XPO1), a member of the karyopherin β family of transport receptors, is an important nuclear export receptor recognizing proteins bearing a leucine-rich nuclear export signal (PMID: 9323133). CRM1 is the major receptor for the export of proteins out of the nucleus and is also required for transport of many RNAs (PMID: 17317185). In addition to nuclear export, CRM1 also plays a role in centrosome duplication and spindle assembly (PMID: 22773955). Elevated CRM1 expression has been reported in several cancers, which implicates CRM1 as a potential anti-cancer drug target (PMID: 22677130; 21683812 ).


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